In recent years, safety testing of nanomaterials has been widely explored, revealing potentially hazardous impacts of ENMs under a variety of experimental conditions. The rapid development of nanomedicine, such as the use of nanocarriers in theranostics and drug delivery, particularly underlines the urgent need for safety assessment of biomedical nanomaterials. Biomedical applications of ENMs have become one of the most prominent areas of research in nanoscience and technology. While exciting, this prospect has also raised concerns about the potential environmental, health and safety (EHS) impacts of ENMs. It is estimated that the sale of nanotechnology-enabled products will grow to more than $4 trillion by 2018. As of May 2014, the Nanotechnology Consumer Products Inventory has recorded more than 1800 nanotechnology-based products on the market. analysis method, nanosafety assessment, library integration approach, high-content screening, nanomaterials INTRODUCTION The rapid development of the field of nanotechnology has promoted numerous engineered nanomaterials (ENMs) to actual or potential application, and the products enabled by ENMs are expected to eventually enter all industrial sectors and almost every aspect of our daily lives.
This integrated approach also allows the safer design of ENMs, which is relevant to the implementation of nanotechnology solutions in the pharmaceutical industry. This systematic approach integrates the use of material and biological libraries, automated HCS and high-content data analysis to provide predictions about the environmental impact of large numbers of ENMs in various categories. We propose the integration of compositional and property-based ENM libraries for HCS of cells and biologically relevant organisms to be screened for mechanistic biomarkers that can be used to generate data for HCS and decision analysis. In this review, we present a ‘Library Integration Approach’ for high-content safety analysis relevant to the ENMs. With this approach, we have to consider reducing and replacing the commonly used rodent models, which are expensive, time-consuming, and not amenable to high-throughput screening and analysis. The rapid emergence and sheer number of new nanomaterials with novel properties demands rapid and high-content screening (HCS), which could be performed on multiple materials to assess their safety and generate large data sets for integrated decision-making. Thus, an integrated approach is urgently required by government, industry, academia and all others who deal with the safe implementation of nanomaterials on their way to the marketplace. Although large amounts of data have been published regarding the potential hazards of these materials, we still lack a comprehensive strategy for their safety assessment, which generates a huge workload in decision-making.
Li, Yiye Wang, Jing Zhao, Feng Bai, Bing Nie, Guangjun Nel, André E Zhao, YuliangĪbstract Safety analysis of engineered nanomaterials (ENMs) presents a formidable challenge regarding environmental health and safety, due to their complicated and diverse physicochemical properties. Nanomaterial libraries and model organisms for rapid high-content analysis of nanosafety Nanomaterial libraries and model organisms for rapid high-content analysis of nanosafety